In One Piece manga chapter 1012, we will see more of Big Mom protecting O-Tama and as a result, for the time being, siding with the Straw Hats. However, it’s unknown which will prevail in the long run, her hatred of the Straw Hats or her love for O-Tama.
Then, there’s the theory that O-Tama‘s ability to control all beasts can work on another Yonko in Kaido. The Emperor of the Sea is technically, half beat and that might make him venerable to O-Tama’s powers. In fact, if it works on Kaido, it will work on several of his crewmembers including King and Queen.
O-Tama’s ability might even work on X-Drake and Marco too but there’s little reason for her to attempt this. In saying that though, as we know it, O-Tama’s abilities only work on Smile users but I’d like to see her at least try on Kaido. As you can see, the possibility of O-Tama being able to control both Kaido and Big Mom, makes her the most dangerous person in Wano right now.