So, I might be predicting this prematurely but based on what we have seen in Boruto manga chapter 52, Boruto Manga Chapter 53 might showcase the death of either Sasuke or Naruto. However, I believe it will be Sasuke and I’ll tell you why.
Hypothetically, if Naruto defeats Isshiki in Boruto manga chapter 52, if he doesn’t and the fight is still taking place in chapter 53 then this prediction will happen a little later on, I doubt Naruto will die. One issue with Naruto passing is that Kurama would also die and Isshiki needs Kurama to unleash the Ten-Tails so, he might prevent Naruto from being killed.
However, Kurama did state that if Naruto accesses the power that he has released against Isshiki in chapter 52, then Naruto’s death will soon follow. So, let’s say that Isshiki can’t save Naruto. We also know that Kawaki mentions that he did something to Naruto in the future, which hints that Naruto was still alive to at least the point of Konoha’s future destruction.
Therefore, Naruto will likely survive the costs of using this power, as Might Guy did after releasing all Eight Gates in the previous war. How though? Well, I believe that Sasuke Uchiha is the key to saving Naruto’s life after the Isshiki threat.
I assume you recall Nagato sacrificing himself to revive the Konoha villages after his attack. Well, it’s possible that Sasuke could use the same technique and because of the near-death state that he is likely in after Isshiki beat him around in chapter 52, using such a technique will likely kill him.
This is why I believe we will see Sasuke Uchiha’s death on Boruto Naruto Next Generations manga chapter 53 instead of Naruto Uzumaki’s. However, we will have to wait at least a couple of months to see if my theory is correct or not.